Micronization Provides Enhanced Bioavailability: Inhaled Delivery, Transdermal Absorption, GI AbsorptionMicronization via jet milling is an established manufacturing technique for improving the solubility of poorly soluble APIs (active pharmaceutical ingredients) and enhancing the overall bioavailability of drug products.  Leveraging high velocity compressed gas; particles are accelerated to supersonic speeds to achieve sub 10 micron (superfine) distributions in order to provide Gaussian distribution curves with superior reproducibility.  The process is ambient due to the instantaneous pressure drop of the grinding gas within the milling chamber cooling the colliding particles which makes jet milling an ideal technology for sensitive pharmaceutical ingredients.
Features of Micronization:
  • Average particle size ranges from 2-10 microns
  • Ambient process
  • Stationary grinding chamber with no moving parts
  • Reproducible & High throughput process
Benefits of Micronization:
  • Improved bioavailability and dissolution of poorly soluble API’s
  • No heat degradation for powder being milled
  • Less risk of metal contamination associated
  • High quality, cost effective milling approach
Applicable FormulationsTypes:
  • Tablets/Capsules
  • Topical creams
  • Suspensions/Injectables